From the Colosseum to the Capitoline Museums, passing through Trastevere, the Doria Pamphilj Gallery, and the Leonardo da Vinci Exhibition: 7 stops to discover Rome in a weekend.
Rome is a city that truly offers countless things to do and see, and it would take weeks to explore it calmly. Still, even if you only have one weekend available, this beautiful city is absolutely worth visiting. In two days, you can alternate monuments, museums, and lesser-known places, creating an itinerary that reveals the different souls of the city.bFor example, you can dedicate the first day to Ancient Rome and its origins, then focus the second day on art, culture, and innovation, alternating outdoor and indoor experiences. Of course, choices are necessary, but even in just one weekend Rome can convey its unique atmosphere.
TABLE OF CONTENTS
- Colosseum and Imperial Forums
- Capitoline Museums
- Trastevere
- Doria Pamphilj Gallery
- Church of Sant’Ignazio di Loyola
- Leonardo da Vinci Exhibition
Colosseum and Imperial Forums
A weekend in Rome can only begin with the Capital’s most famous monument, especially if it is your first time visiting the city. The Colosseum is still one of the most recognizable symbols of Antiquity and makes it possible to understand the extraordinary construction skills reached by the Roman Empire. Inaugurated in 80 AD, the amphitheater hosted public shows, gladiator fights, and large events designed to involve thousands of spectators.
Visiting the Colosseum means entering the heart of Imperial Rome and observing up close one of the most influential buildings in the history of architecture. Its central location also makes it the ideal starting point for exploring the surrounding archaeological area: just a few steps from the Colosseum lies the area of the Imperial Forums, the political, administrative, and religious center of Ancient Rome, where temples, basilicas, monumental arches, and public spaces once formed the heart of city life.
Walking among the ruins allows visitors to observe how the urban fabric developed over the centuries through the interventions of various emperors. The columns, remains of monumental squares, and archaeological finds help recreate the image of one of the greatest metropolises of the ancient world.
In Rome with Leonardo
Add the Leonardo Exhibition to your list of things to do in Rome.
Capitoline Museums
After visiting the archaeological area, the Capitoline Museums are a natural continuation of the itinerary. Considered the oldest public museum in the world, they preserve some of the most significant works in Roman history, including imperial statues, reliefs, inscriptions, and masterpieces such as the Capitoline Wolf and the equestrian statue of Marcus Aurelius.
Visiting these rooms makes it possible to place what you have seen in the Forums into context and better understand the role Rome played in constructing its political and cultural image.
Trastevere
In the late afternoon, Trastevere is an ideal stop for discovering a different side of Rome from the monumental one. The neighborhood preserves a more intimate and everyday atmosphere, made of narrow alleys, lively squares, historic buildings, and views that reveal a more personal image of the city.
Walking along Via della Lungaretta, Vicolo del Cinque, and Piazza Trilussa allows visitors to grasp the most authentic and convivial character of the neighborhood. Among the places to see is the Basilica of Santa Maria in Trastevere, one of the oldest churches in Rome, famous for its medieval mosaics and for the square in front of it, which is especially evocative at sunset.
For those looking for a quieter pause, the nearby Botanical Garden of Rome can also be a good alternative: a large and peaceful green space, useful for alternating the urban visit with a slower moment, especially on hot days.

Doria Pamphilj Gallery
The second day can begin with a visit to the Doria Pamphilj Gallery, perhaps less known than other museums in the city but extraordinarily rich from an artistic point of view, as it preserves one of the most important private collections in Rome.
The historic rooms of the palace house works by Caravaggio, Velázquez, Titian, and Raphael, as well as an important collection of furnishings, decorations, and period objects preserved inside an exceptionally beautiful Roman aristocratic residence.

Church of Sant’Ignazio di Loyola
Among the less obvious places to include in a weekend in Rome is the Church of Sant’Ignazio di Loyola, which houses one of the most surprising examples of Baroque perspective illusionism.
The fresco created by Andrea Pozzo gives the impression of a large dome that in reality does not exist. This extraordinary optical effect continues to amaze visitors from all over the world and represents one of the most fascinating artistic curiosities in the historic center.
Leonardo da Vinci Exhibition
The final stop of the itinerary leads to Palazzo della Cancelleria, home to the Leonardo da Vinci Exhibition. After exploring Ancient Rome, major museums, and Renaissance masterpieces, the exhibition offers a perspective dedicated to the relationship between art, science, and innovation.
The exhibition route includes working machines, models, and reconstructions inspired by Leonardo’s codices, allowing visitors to understand Leonardo’s working method in a concrete way. The visit also includes access to the archaeological underground levels of the palace, where the Tomb of Aulus Hirtius and the ancient Euripus of the Campus Martius are preserved.
Thanks to its location in the heart of the historic center, the Leonardo Exhibition can easily be combined with a walk through Piazza Navona and Campo de’ Fiori, both reachable in just a few minutes on foot from Palazzo della Cancelleria.
A Unique Idea for Your Visit
For a different kind of experience in Rome, explore the interactive Leonardo da Vinci Exhibition
You can read the Italian version of this article here >